Endocrine Abstracts

Introduction: Hyponatremia can be a life-threatening emergency. Severe hyponatremia may occur in patients with hypopituitarism and secondary adrenal insufficiency and hypothyroidism. The acute decompensation of pituitary insufficiency can also lead to accompanying rhabdomyolysis and acute renal failure (ARF).Case report: A 67-year-old woman complaining of general fatigue, dizziness, nausea, feeling cold and numbness of limbs and tongue was admitted to th...

Introduction: Rapid deterioration of health condition in patient with diagnosed neoplastic disease, especially metastatic one, requires consideration of cancer progression. However other rare severe complications can occur. In 0.6–0.7% patients with medullary thyroid cancer (MTC) the ectopic ACTH syndrome (EAS) is observed. Hereby, we present a case EAS in patient suffered from MTC.Case report: A 37-year-old man was admitted to the Department of Int...

Introduction: Survivin is a multifunctional protein and acts as an inhibitor of apoptosis. Its expression occurs in nearly all human cancers. In some tumors survivin expression correlates with the malignant behavior and diminished response to cytotoxic therapy. Data concerning survivin expression in invasive pituitary gland adenomas are contradictory.Patients and methods: Survivin expression was assessed in 38 invasive pituitary gland adenomas (31 non-fu...

Introduction: Hepcidin is an acute-phase protein and a key regulator of iron homeostasis. Anemia frequently occurs in patients with hyperthyroidism, while hepcidin may be a potential link.Objectives: Prospective evaluation of hepcidin serum concentration and other parameters related to Fe homeostasis in group of hyperthyroid patients in the course of Graves’ disease (GD) at diagnosis and after restoration of euthyroidism.Pati...

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly occurring if one of the thyroid lobes fails to develop. Due to limited literature data and lack of large-cohort case–control studies, the clinical significance and management with patients in whom TH was diagnosed, are still a matter of debate. The objective of the study was a complex analysis of a large group of patients with TH in comparison to a control group of subjects born with normal, bilobed thyroid ...

Background: Thyroid hemiagenesis (TH) is a rare inborn anomaly, occurring if one of the thyroid lobes fails to develop. Due to mostly asymptomatic course, it is usually detected incidentally, during investigation of concomitant abnormalities of the thyroid function or structure.Case report: A case of Graves’ hyperthyroidism following primary hypothyroidism due to Hashimoto’s thyroiditis (HT), accompanying a TH, is reported. The patient first pr...

Introduction: Thyroid hemiagenesis (TH) is a rare inborn anomaly of unclear importance. The aim of the study is to describe clinical, hormonal and autoimmunological profile of patients with TH.Material and methods: The studied group consisted of 20 subjects (4 men), diagnosed of having TH at the age from 15 to 63. Laboratory tests, including measurement of serum concentration of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free tri...

Amiodarone is frequently used in cardiac patients but has side effects which effects the thyroid due to its high iodine content. The use of radioiodine in AIH with low iodine uptake is controversial. In these patients therapeutic choices for refractory cases include either: surgery, antithyroid drugs, or glucocorticosteriods.What are the treatment choices in elderly patients which can’t be operated on, agranulocytosis is present, or have toxic liver...

Introduction: There are not many studies specifying the role and contribution of adipocytokines in biology of adrenal gland cancer. Many research show correlation between increased level of serum visfatin and malignant potential, stage progression and prognosis. Visfatin/NAMPT overexpression has been found in a various type of malignances. So far, to the best of knowledge, this is the first research studying the role of visfatin in diagnosis of adrenal cortical carcin...

Background: Immuglobulin 4 (IgG4) is the least common subtype of Immoglobulin G. However due to its unique characteristic it has been the focal point of many research projects, which eventualy led to the discovery of the sytemic fibro-inflammatory disorder called IgG4-Related Disease. The potential role of IgG4 in the pathogenesis of autoimmune thyroid diseases has been also suggested. However, the amount of evidence is still limited, especially in Graves Disease (GD).<p c...